When Noel Coward heard Tammy Grimes sing in cabaret, it was the beginning of a lifelong personal and professional friendship. Coward immediately cast her in the leading role in his play Look after Lulu (Theater World Award) and made her a Broadway star. That role led to her being cast in the title role of The Unsinkable Molly Brown for which she won the Tony Award for Best Actress in a musical and about which Walter Kerr wrote, "She is a genius." Ten years later it was Coward´s casting again, this time as Amanda in Private Lives. Kerr reported, "She remains a miracle," and she won her second Tony Award, this time as Best Dramatic Actress. Between and after her two Tony Awards, Grimes has performed to high acclaim on Broadway and off-Broadway in both plays and musicals including: Clerambard, The Littlest Revue, Bus Stop, Rattle of a Simple Man, High Spirits (Coward again — in a musical adaptation of his play Blithe Spirit), Trick, Tartuffe, California Suite, 42nd Street (musical), Orpheus Descending, Mademoiselle Colombe (OBIE), The Imaginary Invalid, The Millionaires, The Guardsman, The Cradle Will Rock (musical), A Month in the Country, Blithe Spirit, Waltz of the Torreodors, The Importance of Being Earnest, Molly, Cocktail Hour, Tammy Grimes in Concert (musical), A Little Night Music (musical) and Pygmalion. Her Shakespearean plays include: Henry IV, Part One, Winter´s Tale, Taming of the Shrew and Twelfth Night.
Grimes has also had a flourishing screen career. Her films include: Mr. North, Slaves of New York, Finnegan´s Wake, The Runner Stumbles, Three Bites of the Apple, Somebody Killed Her Husband, America, No Big Deal, The Last Unicorn (animated), Can´t Stop the Music, The Stuff, A Modern Affair, Trouble on the Corner and High Art.